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Moreover, GLP-1 receptors interact with various neurotransmitter systems such as serotonin, dopamine, and glutamate, which are essential for mood regulation and may contribute to the onset of depression and other psychological disorders [82]

Slides were rinsed in tap water and treated with 1% H 2 O 2 in Tris-buffered saline for 15 minutes and rinsed in Tris-buffered saline followed by avidin/biotin blocking

Compared to peptide GLP- 1 receptor agonists, orforglipron, exhibits less receptor desensitization by increasing cyclic AMP signaling [105]

Potential adverse laboratory findings require clinical judgment to interpret appropriately